HSE will be running the initiative.
The HSE will be back at Electric Picnic this year for on-site drug checking.
Its aim is to provide harm reduction to identify drugs that pose a risk, and allow people to surrender drugs for the purpose of testing.
Trained volunteers will be at three locations this weekend, while five bins will be available for people to give up drugs.
Nicki Killeen, HSE Emerging Drugs Trends Project Manager, says it's important people tell medics what they've taken if they're suffering an emergency: