He faces third seed Stefanos Tsitsipas this evening.
The US Open gets underway at Flushing Meadows in New York this afternoon.
The former world number one Andy Murray faces third seed Stefanos Tsitsipas this evening.
Daniil Medvedev, Naomi Osaka and Coco Gauff are also in first round action later.
Dan Evans faces Brazil's Thiago Monteiro, before Cameron Norrie meets Carlos Alcaraz of Spain.
In the women's draw, British number one Johanna Konta goes up against Kristina Mladenovic, Heather Dart also faces French opposition in Caroline Garcia and Heather Watson takes on Slovenian Kaja Juvan.