It's the club's sixth defeat of the season.
Portlaoise Panthers' difficult start to life in the MissQuote.ie Super League continued over the weekend.
The Laois club suffered their sixth defeat of the season away to University of Galway Mystics on a scoreline of 75-61on Saturday.
The result leaves Niall Berry's side just one place above the bottom in 10th place ahead of their opponents, as this was their first win of the season.
Panthers return to action away to SETU Waterford Wildcats on Saturday evening.