Peamount United are the first opponents for the midlanders.
Athlone Town Women get their FAI Cup defence up and running this weekend.
Lily Agg's side travel to Dublin to take on two time winners Peamount United, looking to progress to the third round.
Agg won her first game in charge of the club two weeks ago as her side saw off Shamrock Rovers 3-1 at home, while their opponents are on a four game losing streak.
Kick off from Greenogue is at 5pm this Saturday.
Offaly SFC: Tullamore Begin Hunt For Fourth Title In A Row
World Cup: Harry Kane Brace Sends England To Round Of 16
Westmeath SHC: Clonkill And Raharney The Headline Opening Game
Casey O'Gorman Secures Top 10 Moto3 Finish In The Netherlands
Seir Kieran Hoping To Kick On Following Division One League Success
Midlands Athletes Shine At National Juvenile Track & Field Championships
Leinster Community Heroes Winners Announced
Offaly Ladies Footballers Miss Out On Knockout Stages Of Junior Championship
Athlone Town Denied League Win At Home To Finn Harps
We Can Build On This Year And Get More Competitive - Amy Byrne
Joe Ward Set To Fight This August
Offaly Soccer Club Seeks Green Light For Major Facilities Expansion
Offaly Camogie Maintain Senior Status For 2027
Alex Dunne Finishes 7th At Austrian Grand Prix In Formula 2
World Cup: Canada Win Opening Round Of 32 Match
Travelers Championship To Be Completed By Play-Off
Westmeath Ladies Seal All-Ireland Semi-Final Spot