The Dublin side were too strong for Jack Scully's team.
Portlaoise Panthers suffered a first home defeat of the season in Division One.
Jack Scully's side were beaten by Dublin Lions on Saturday evening, with the game ending 74-66 in favour of the visitors.
Despite, Michael Wallace leading the way for Panthers with 21 points, it wasn't enough to continue their 100% home record.
The club have slipped to second in the table.
Panthers return to action on December 27th at home to Limerick Sport Eagles.
James Gormley Named On Irish Squad For FIBA EuroBasket Qualifiers
Portlaoise Panthers Suffer Tough Defeat In Super League
CCFL: St Peter's Extend Their Advantage At Top Of Premier Division
NFL: Relegation Firmly On The Cards For Offaly
Laois "Devastated" By Defeat Despite Delivering "Manliness" - Justin McNulty
Westmeath Ladies Bag First Win Of League Season
Big Camogie Wins for Westmeath and Laois Over The Weekend
Fitzgerald "Relieved" After Squeaking Past Kerry
NHL: Galway Prove Too Strong For Offaly
Former Laois And Offaly GAA Manager Honoured By An Garda Síochána
Athlone Town Make It Two Wins From Two In First Division
Lee Fitzpatrick Scores Try For Ireland U20s In England
NFL: Westmeath Move Closer To Promotion
Shane Lowry Finishes Strong In California
Westmeath Drifter Sets Sights On Success In 2026
Offaly’s Alex Dunne Joins Alpine’s Young Driver Programme
NHL: Laois And Kerry Clash In Division Two
Shane Lowry Cards Opening Round 73 At Genesis Invitational
Athlone Town Aiming For Back To Back League Wins