The Dublin side were too strong for Jack Scully's team.
Portlaoise Panthers suffered a first home defeat of the season in Division One.
Jack Scully's side were beaten by Dublin Lions on Saturday evening, with the game ending 74-66 in favour of the visitors.
Despite, Michael Wallace leading the way for Panthers with 21 points, it wasn't enough to continue their 100% home record.
The club have slipped to second in the table.
Panthers return to action on December 27th at home to Limerick Sport Eagles.
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