England have picked their first choice back row for the game.
James Ryan will lead an Ireland captain's run for the first time today.
Former Ireland captain Keith Wood says Ireland will face a very physical test against England on Saturday.
Eddie Jones has restored Tom Curry, Sam Underhill, Mako Vunipola and Kyle Sinckler to their pack for the Autumn Nations Cup clash.
It may not have been flashy, but Wood says England’s win over Georgia shows what awaits Ireland at Twickenham.
Ireland will play the United States and Canada should they qualify for next year’s Women’s World Cup.
Ireland were due to play a qualifying tournament next month, but it’s been suspended due to COVID-19 restrictions.
Should they win that mini-tournament, they’ll be in Pool B for next year’s finals in New Zealand.