Robbie Henshaw's try scoring performance against Australia failed to secure his place against South Africa.
There's no place for Robbie Henshaw in the matchday squad for Ireland's November series international against South Africa.
The Athlone man misses out as Garry Ringrose and Bundee Aki return to the Irish midfield.
Elsewhere Sam Prendergast has retained his place at outhalf, with Andrew Porter selected in the front row alongside Dan Sheehan and Tadgh Furlong.
Caelan Doris is selected at number eight, which means Jack Conan starts on the bench while Josh Van Der Flier starts in the backrow alongside Ryan Baird.
Buccaneers' South African Head Coach Darin Claasen says the Springboks will have had the contest circled from a long way out:
Saturday's final autumn international kicks off at the Aviva Stadium at 5.40pm.
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