The Leinster centre has failed to recover for the middle game of this year's campaign.
Andy Farrell has refreshed his Ireland squad ahead of Saturday’s Six Nations test away to Italy.
Joey Carbery returns to the fold, having been omitted from the squads that beat Wales and France.
With Tadhg Beirne and Joe McCarthy out injured, Scott Penny and Kieran Treadwell have received call-ups.
Dan Sheehan and Cian Healy have been passed fit following hamstring injuries.
But Tadhg Furlong, Robbie Henshaw and Jamison Gibson-Park all remain absent.
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