Wexford come into the game on the back of promotion to Division Three.
The Leinster Championship kicks off this weekend as Laois get their campaign underway against Wexford in the Preliminary Round.
The O'Moore County had a mixed league season finishing just above the drop on six points, having won three of their seven games played.
Last weekend's Division four final defeat to Limerick represented the first loss of the campaign for Wexford, having previously been the only team in Ireland to win all of their league games.
Laois Manager Justin McNulty says his side face a a major challenge.
Throw in is at six o'clock at Chadwicks Wexford Park on Saturday evening.
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