Wexford come into the game on the back of promotion to Division Three.
The Leinster Championship kicks off this weekend as Laois get their campaign underway against Wexford in the Preliminary Round.
The O'Moore County had a mixed league season finishing just above the drop on six points, having won three of their seven games played.
Last weekend's Division four final defeat to Limerick represented the first loss of the campaign for Wexford, having previously been the only team in Ireland to win all of their league games.
Laois Manager Justin McNulty says his side face a a major challenge.
Throw in is at six o'clock at Chadwicks Wexford Park on Saturday evening.
Keeping Up Unbeaten League Start The Aim For Athlone Town Women
Two Pointer Rule Makes Big Difference To Gaelic Football - Emmet McDonnell
Shane Lowry Records Opening Round Of 72
Tullamore Town FC Ready For Red Letter Weekend
Busy Bank Holiday Weekend In Store For Athlone Town
Big Weekend Ahead In Leinster Minor And U20 Hurling Championships
Leinster SFC: Opportunity Beckons For Westmeath
Westmeath Footballer Luke Loughlin Ruled Out For Remainder Of Season
Laois And Westmeath Battle For Place In Leinster LGFA Decider
Alex Dunne Set For Action In Miami This Weekend
Fundraising Walk Planned For Westmeath Man Left Paralysed In Freak Accident
Shane Lowry In Action In Miami This Week
Westmeath Secure Leinster Minor Football Quarter Final
CCFL: Two Draws In Senior Division
Potential Hometown Fight On The Cards For Joe Ward
Ava O'Connor Breaks Personal Steeplechase Record
Laois Fixture In Two Weeks A "Massive Game" - Kevin O'Brien
Camross Camogie Honoured In Laois Following Historic All-Ireland Triumph
Athlone Town Secure Vital Win In Women's Premier Division
Laois And Westmeath To Clash In Leinster Camogie Decider