Leo Cullen will have to do without at least five Irish internationals.
Leinster will be without 11 players for next weekend's trip to face Exeter in the Champions Cup.
Leo Cullen won't have Irish Internationals Gary Ringrose, Will Connors, Calen Doris, James Ryan or Dan Leavy available.
Jamison Gibson-Park is also now a doubt with a hamstring injury picked up in training.
Frenchman Mathieu Raynal has been appointed as the referee for the meeting of the last two winners.