The Clara man will be hoping to bring his PGA Championship form to Pinehurst.
The third major of the year, the US Open, begins at Pinehurst in North Carolina today.
2019 Open Champion Shane Lowry tees off just after a quarter to 7 this evening.
The Offaly golfer registered an impressive 6th place finish at the PGA Championship after equaling the course record on his third round.
Tom McKibbin is making his major debut
He tees off his opening round at 11.45am Irish time, with Seamus Power out just before Noon.
McIlroy hits the fairways just before 6.15pm.
He'll tee off alongside world number one Scottie Scheffler and PGA Champion Xander Schauffele.
The Northern Irishman's hoping a strong performance at Pinehurst will land him an elusive fifth major title.
He says it'll be no disadvantage being involved in such a strong group:
World number one Scottie Scheffler is bidding for his sixth win of 2024.
Laois SFC: Killeshin Deliver Knockout Blow To Portlaoise
Westmeath SFC: Moate All Whites Turn Attention To County "Standard Bearers"
Town Continue Rich Vein Of Form With Creditable Students Draw
Offaly SFC: Shamrocks And Tullamore Secure Semi-Final Spots
John Heslin Aiming To Feature For Westmeath Next Season
Westmeath SFC: St Loman's Mullingar And Moate All Whites Progress
Athlone Town Move Closer To Women's Premier Division Title
Alex Dunne Keeps F2 Title Hopes Alive With Spanish GP Podium
I've Great People Around Me - Shane Lowry
Trump To Lift US Tariff On Irish Whiskey After Talks With Shane Lowry
Lowry Breaks Title Drought With Magnificent Irish Open Victory
Shane Lowry Leading The Way At The Irish Open
Alex Dunne Secures Front Row Start For F2 Feature Race In Madrid
Former Golf Coach Stunned With Stuart Grehan Not Competing At Irish Open
Treaty United The Next Test For Athlone Town
Mark McHugh To Remain In Charge Of Westmeath Footballers
Cannonball 2026 Heading For Offaly Today
Westmeath SFC: St Loman's Mullingar Aiming To Push Forward
Laois SFC: Places In The Semi-Finals Up For Grabs