They were beaten 3-2 by German's RB Leipzig.
Manchester United gave themselves too much to do last night.
Ole Gunnar Solskjaer's side, who just needed a draw to advance to the last 16 of the Champions League, were beaten 3-2 away to RB Leipzig in their final group game.
The German side went 3-0 up before United scored twice in the last 10 minutes through Bruno Fernandes and Paul Pogba.
However, the Red Devils came up short and now have Europa League football to look forward to in the New Year.
Manager Ole Gunnar Solskjaer says the buck stops with him.
Joining Leipzig in the last-16 will be Paris Saint-Germain. However, their game with Istanbul Basaksehir will need to be completed this evening.
Following accusations of racism levelled against the fourth official in Paris, both sets of players left the pitch.
UEFA have promised a full investigation, and a new officiating team will take charge of the game from the thirteenth minute at 5.55.
Elsewhere, Chelsea completed their successful Group E campaign with a 1-1 draw against Krasnodar at Stamford Bridge.
Cristiano Ronaldo scored two penalties as Juventus won 3-0 at Barcelona.
Both sides were already through.
Keeping Up Unbeaten League Start The Aim For Athlone Town Women
Two Pointer Rule Makes Big Difference To Gaelic Football - Emmet McDonnell
Shane Lowry Records Opening Round Of 72
Tullamore Town FC Ready For Red Letter Weekend
Busy Bank Holiday Weekend In Store For Athlone Town
Big Weekend Ahead In Leinster Minor And U20 Hurling Championships
Leinster SFC: Opportunity Beckons For Westmeath
Westmeath Footballer Luke Loughlin Ruled Out For Remainder Of Season
Laois And Westmeath Battle For Place In Leinster LGFA Decider
Alex Dunne Set For Action In Miami This Weekend
Fundraising Walk Planned For Westmeath Man Left Paralysed In Freak Accident
Shane Lowry In Action In Miami This Week
Westmeath Secure Leinster Minor Football Quarter Final
CCFL: Two Draws In Senior Division
Potential Hometown Fight On The Cards For Joe Ward
Ava O'Connor Breaks Personal Steeplechase Record
Laois Fixture In Two Weeks A "Massive Game" - Kevin O'Brien
Camross Camogie Honoured In Laois Following Historic All-Ireland Triumph
Athlone Town Secure Vital Win In Women's Premier Division
Laois And Westmeath To Clash In Leinster Camogie Decider