They open up their Six Nations campaign against Wales.
Offaly's Nichola Fryday will captain Ireland for the first time this weekend.
She's been named in the second row for the Tik Tok Six Nations clash with Wales at the RDS.
Portlaoise's Emma Hooban is among the replacements.
In his first game in charge, McWilliams has opted for an exciting blend of youth and experience in his side having worked closely with the extended squad during a series of preparatory camps at the IRFU High Performance Centre.
Linda Djougang, Neve Jones and Katie O’Dwyer are named to start in the front row, with Sam Monaghan joining newly-appointed captain Fryday in the second row.
Dorothy Wall has returned from injury having missed last Autumn’s November Series to start at blindside flanker, with Edel McMahon selected at openside and Brittany Hogan at number eight.
Reilly, who has featured on the HSBC World Rugby Sevens Series for Ireland, partners Nicole Cronin in the half-backs, with the Limerick native returning to the green jersey to win her 17th Test cap.
There is a new-look centre partnership with Stacey Flood linking up with Eve Higgins in midfield, while Lucy Mulhall, Amee-Leigh Murphy Crowe and Eimear Considine make up an exciting back three.
Haney and McGann are among the replacements tasked with making a big impact, with Hooban, Chloe Pearse and Hannah O’Connor providing the other reinforcements for McWilliams up front. Kathryn Dane, Enya Breen and Beibhinn Parsons complete the 23.
It's a 4:45pm kick-off.
Commenting on his selection, McWilliams said:
"This is a great start for us as a group, we’re really excited about the youth and experience in the team. We’ll learn a lot from this game, but for these players to go out and represent Ireland at the RDS is going to be special. It’ll be a great occasion and I’m excited to see how they perform, because we’ve got through a lot of work over the last couple of weeks."
NHL: Offaly Face Limerick In Final League Game
Portlaoise Panthers Looking To Continue Good Form In Division One
Shane Lowry In Action In Florida This Week
NHL: Improving Each Week The Goal For Laois
Grainne Walsh Progresses At Strandja Memorial Tournament
Crunch Weekend For Midlands Sides In National Camogie League
James Gormley Named On Irish Squad For FIBA EuroBasket Qualifiers
Portlaoise Panthers Suffer Tough Defeat In Super League
CCFL: St Peter's Extend Their Advantage At Top Of Premier Division
NFL: Relegation Firmly On The Cards For Offaly
Laois "Devastated" By Defeat Despite Delivering "Manliness" - Justin McNulty
Westmeath Ladies Bag First Win Of League Season
Big Camogie Wins for Westmeath and Laois Over The Weekend
Fitzgerald "Relieved" After Squeaking Past Kerry
NHL: Galway Prove Too Strong For Offaly
Former Laois And Offaly GAA Manager Honoured By An Garda Síochána
Athlone Town Make It Two Wins From Two In First Division
Lee Fitzpatrick Scores Try For Ireland U20s In England
NFL: Westmeath Move Closer To Promotion
Shane Lowry Finishes Strong In California