The Laois club are into the competition's last four for the first time.
The Portlaoise Panthers have booked a spot in the semi-finals of the President's National Cup for the first time.
The Panthers were comfortably ahead in the second quarter by 25 points, before Drogheda Wolves came back impressively in the second half.
After being reeled in the Laois club re-found their feet thanks to important contributions from James Phelan, Eric Anderson and Xabi Arriaga.
The final score was 82-69.
Jack Scully's side return to action in the National League First Division against SETU Waterford Vikings this weekend.
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