Niall Berry's side earned their first win of the season last time out against DCU Mercy.
After a two week break, the Portlaoise Panthers return to action in the MissQuote.ie Super League this weekend.
Niall Berry's side travel to University of Galway Mystics off the back of securing their first win of the season at home to DCU Mercy in their last outing.
Victory here will be the team's first away from home and will be the first time they record back-to-back wins this season.
Their game against University of Galway Mystics gets underway at 4:00pm on Saturday from Kingfisher Sports Arena.