The ladies will take a trip to Cavan, while the men's side will venture to Donegal in this weekend's fixtures.
Portlaoise Panthers are in action for first time in 2023 this weekend.
The women's side take on McEvoy's Cavan Eagles on Sunday in the MissQuote.ie National League Division One.
Panthers were losers last time they took the court, falling to a three-point deficit at the hands of Marble City Hawks.
Tip-off at the Virginia Show Centre is at 4pm.
Meanwhile, the men's squad are looking to build on back-to-back victories this weekend.
They travel to Donegal to take on Team North West in the InsureMyVan.ie National League First Division.
Panthers have two wins under their belt so far this calender year, getting the better of Abbey Seals Dublin Lions and most recently Malahide at home in St. Mary's Hall.
Tip-off at the ATU in Donegal is at 5pm.
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