They face the challenge of Dublin and Louth respectively.
Offaly's minor footballers may only have wrapped up their 2020 campaign a week ago but they're back in action tomorrow.
Dublin are the visitors to O'Connor Park in Tullamore.
Both sides received a bye to make it to this stage owing to their performance in last season's championship.
Ken Furlong has named his team this morning.
Offaly starting XV:
David Dunican; James Mahon, Ben Heffernan, Dylan Kilmurray; Patrick Taaffe, Darragh McKeown, Adam Daly; Geordi O' Meara, Donal Shirley; Cathal Guinan, Marcus Dalton, Luke Bourke; Conor Dunican, Cian O'Reilly, Robbie Gallagher.
Laois are also in action as they travel east to face Louth.
The O'Moore country progressed to this stage after overcoming Wexford back in June.
Goalkeeper Conor Brown was the hero as he saved a couple of penalties after the game finished 1-11 to 0-14.
Laois overcoming the odds when they played with thirteen men for twenty minutes of that encounter.
Both games have a noon throw-in tomorrow.
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