Johnny Sexton will also miss the game.
Ireland have a number of injuries to contend with ahead of this Saturday's Autumn Nations Cup test against England at Twickenham.
Johnny Sexton and Robbie Henshaw have both been ruled out of the game after picking up injuries in Friday's win versus Wales.
Sexton has a hamstring issue, while Henshaw has a groin strain.
Jacob Stockdale is also a doubt, having missed the Wales match with a calf injury, but Iain Henderson and Shane Daly have returned to training.
Sexton's replacement Billy Burns is currently following the return to play protocols after a head injury, leading to doubts over who will play at outhalf this weekend.
Head coach Andy Farrell has suggested that Conor Murray could be an option in that position, but former Irish international Alan Quinlan thinks it would be a risky move.
Shane Lowry Leading The Way At The Irish Open
Alex Dunne Secures Front Row Start For F2 Feature Race In Madrid
Offaly SFC: Semi-Final Spots Up For Grabs
Former Golf Coach Stunned With Stuart Grehan Not Competing At Irish Open
Treaty United The Next Test For Athlone Town
Mark McHugh To Remain In Charge Of Westmeath Footballers
Cannonball 2026 Heading For Offaly Today
Westmeath SFC: St Loman's Mullingar Aiming To Push Forward
Laois SFC: Places In The Semi-Finals Up For Grabs
Shane Lowry Aims To Win Second Irish Open
Laois Soccer Club Plans New Clubhouse And Changing Facilities
Westmeath SFC: Tyrrellspass Secure Survival
Shane Lowry Learns Tee Off Time Ahead Of Irish Open
Walker Cup Victory Loudest Roar I've Ever Experienced - Stuart Grehan
GAA ‘Not Ready’ For Proposed Integration With LGFA And Camogie Association
Offaly SHC: It's Great To Be Back In The Semi-Finals - Brian Duignan
Athlone Town Take Big Leap Towards Defending League Title
Westmeath Photographer Captures Katie Taylor’s Retirement Fight At Croke Park