Robbie Henshaw has retained his place.
Warren Gatland has made six changes for the final Lions test in South Africa.
Robbie Henshaw retains his place but is joined in the centre by Irish partner Bundee Aki.
Josh Adams and Liam Williams both come into the back three, with Ali Price coming in at half-back.
In the pack Wyn Jones gets the nod at loosehead and Ken Owens is introduced at hooker.
“The matchday 23 have an incredibly special opportunity in front of them – to seal a Lions Series victory in South Africa,” said Gatland.
“It doesn’t get much bigger than this and we’re excited by the challenge that faces us on Saturday.
“We’ve no excuses from last week, the Springboks put us under pressure in the second half and deserved the win. We have to be much better than that second half performance, and I believe we will be.”
The Lions Team v South Africa:
15. Liam Williams (Scarlets, Wales) #833
14. Josh Adams (Cardiff Rugby, Wales) #836
13. Robbie Henshaw (Leinster Rugby, Ireland) #824
12. Bundee Aki (Connacht Rugby, Ireland) #837
11. Duhan van der Merwe (Worcester Warriors, Scotland) #841
10. Dan Biggar (Northampton Saints, Wales) #821
9. Ali Price (Glasgow Warriors, Scotland) #843
1. Wyn Jones (Scarlets, Wales) #842
2. Ken Owens (Scarlets, Wales) #829
3. Tadhg Furlong (Leinster Rugby, Ireland) #818
4. Maro Itoje (Saracens, England) #825
5. Alun Wyn Jones – captain (Ospreys, Wales) #761
6. Courtney Lawes (Northampton Saints, England) #826
7. Tom Curry (Sale Sharks, England) #853
8. Jack Conan (Leinster Rugby, Ireland) #839
Replacements:
16. Luke Cowan-Dickie (Exeter Chiefs, England) #851
17. Mako Vunipola (Saracens, England) #787
18. *Kyle Sinckler (Bristol Bears, England) #814 – subject to outcome of disciplinary hearing.
19. Adam Beard (Ospreys, Wales) #852
20. Sam Simmonds (Exeter Chiefs, England) #849
21. Conor Murray (Munster Rugby, Ireland) #790
22. Finn Russell (Racing 92, Scotland) #835
23. Elliot Daly (Saracens, England) #822
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