There was another shock exit last night.
Women's top seed Karolina Pliskova suffered a shock second round exit at the US Open last night.
She lost in straight sets to the world number 50, Caroline Garcia.
Men's top seed Novak Djokovic needed four sets to see off England's Kyle Edmund.
Fifth seed Alexander Zverev also needed four sets to beat world number 223 Brandon Nakashima.
After Tuesday's five set epic, Andy Murray's in second round action against Canadian Felix Auger-Aliassime.
Serena Williams faces Margarita Gasparyan of Russia.