The company announced the decision to close all of its pharmacies, including at its Laois store.
Tesco is closing its pharmacy in a midlands store.
The decision comes following an extensive review of the service, and all seven pharmacies, including in Portlaoise, will close at the end of next month.
Tesco say its trained pharmacists and teams will be on-hand to support patients throughout the next six weeks.
In a statement to Midlands 103, the company is also thanking its customers for understanding, and have given assurances it is committed to providing a smooth transition.
Statement from Tesco Ireland:
"We recently completed an extensive review of our pharmacy offering in Ireland, and for operational reasons have made the difficult decision to close all seven Tesco operated pharmacies across the country at the end of April 2023.
We understand that patients and customers will have questions, and our trained pharmacists and pharmacy teams will be on hand to support them through this change. We thank them for their understanding and assure them that we are committed to providing a smooth transition over the coming weeks."