Bundee Aki replaces Robbie Henshaw in the centre.
Head coach Andy Farrell's made four changes to his starting fifteen for Saturday's Autumn Nations Cup match against England.
Two of the changes are enforced with outhalf Johnny Sexton and Robbie Henshaw ruled out of the Twickenham clash through injury.
Ross Byrne and Bundee Aki come in to replace them.
Keith Earls starts on the wing in place of Andrew Conway who is left out of the matchday squad but Jacob Stockdale is named in the replacements.
CJ Stander replaces Josh van der Flier in the only change to the pack.
Team in Full:
15. Keenan, 14. Earls, 13. Farrell, 12. Aki, 11. Lowe, 10. R. Byrne, 9. Gibson Park;
1. Healy, 2. Kelleher, 3. Porter, 4. Roux, 5. Ryan (C), 6. Stander, 7. O'Mahony, 8. Doris.