The former Buccaneers man will be joined by Garry Ringrose in Ireland's Centre.
Robbie Henshaw has retained his starting place in Ireland's team to take on South Africa in the second and final test of Ireland's tour this weekend.
The Athlone man will partner Garry Ringrose who comes in for Bundee Aki who misses out with what's understood to be an arm injury.
Conor Murray comes into the team in place of the injured Craig Casey.
And Rónan Kelleher replaces the injured Dan Sheehan.
South Africa won the first test 27-20 on Saturday.
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