Andy Farrell has named his team for their meeting with Wales.
Athlone's Robbie Henshaw will start for Ireland in their opening Autumn Nations Cup game against Wales.
He will partner Chris Farrell in the centre at 7pm on Friday evening.
James Lowe makes his debut on the wing, while Ulster's Billy Burns could also win his first cap from the bench.
Jacob Stockdale continues at fullback while Hugo Keenan has swapped wings to accommodate Lowe.
#TeamOfUs— Irish Rugby (@IrishRugby) November 10, 2020
📄 𝗧𝗲𝗮𝗺 𝗔𝗻𝗻𝗼𝘂𝗻𝗰𝗲𝗺𝗲𝗻𝘁 🟢
Andy Farrell has named his Ireland team to face Wales in Friday's #GuinnessSeries opener at @AVIVAStadium, including a debut for James Lowe 🙌#ShoulderToShoulder #AutumnNationsCup #IREvWAL pic.twitter.com/5GNqYvylLg