Both men's and women's sides will face Limerick Celtics.
Basketball Ireland has released the National League fixtures for the 2020/21 season.
Portlaoise Panthers men's and women's are in action in Division One of the South Conference on the opening weekend.
Both teams play Limerick Celtics next Saturday 17th.
The women take to the court at 6pm, with the men at the later time of 8pm.