Panthers now sit with a 2-9 record in the division.
Portlaoise Panthers were on the end of a heavy defeat on the road in the Super League over the weekend.
Utility Trust St. Pauls Killarney proved too strong for the challenge of the Laois side, as they came away with a 69-44 victory.
Maisie Burnham impressed for the Kerry side as she finished with a total of 20 points for Killarney.
Panthers return to action at home to McEvoy’s Cavan Eagles in two weeks time.
CCFL: St Peter's And Willow Park Continue To Impress
Athlone Town Aiming To Kick Off New Season With Silverware
Portlaoise Panthers Suffer Home Defeat In Women's Super League
Buccaneers Suffer Heavy Defeat Away To Navan
NFL: Laois Were Superior Than Us In The Second Half - Mark McHugh
NHL: Promotion Within Touching Distance For Laois
Athlone Town Remain Unbeaten In First Division
Draw Made For Laois Senior Club Championships
Grainne Walsh Wins Bronze At Strandja Memorial Tournament
NHL: Laois Too Strong For Westmeath In Division Two
Clinical Offaly Claim First Win In National Camogie League
NHL: Relegation From Division 1A Confirmed For Offaly
NFL: Laois Claim Midlands Bragging Rights In Division Three
Mixed Weekend In Division One For Portlaoise Panthers
Laois, Offaly And Westmeath Suffer Defeats In National Ladies Football League
Back To Back Double Bogeys Denies Shane Lowry Victory In Florida
Offaly Travel To Tyrone In National Football League
Three AIL Wins In A Row The Aim For Buccaneers This Weekend