Stephen Kenny will be hoping for another brace of goals against Luxembourg.
The Republic of Ireland opened up their World Cup qualification campaign with a 3-2 defeat to Serbia in Group A in Belgrade last night.
Manager Stephen Kenny has now gone nine games without a victory.
Alan Browne ended Ireland's goal drought by opening the scoring, while James Collins scored the Boys in Green's second, five minutes from the end.
But a strike by Dusan Vlahovic and two second half goals from Aleksandar Mitrovic were Ireland's undoing.
Kenny was frustrated by the absence of V-A-R.
Next up is a Saturday evening visit of Luxembourg to the Aviva Stadium.