A similar facility in Mullingar will open later this week.
334 covid vaccines were administered on the opening day of the mass vaccination centre in Tullamore.
The centre at the Tullamore Court Hotel opened to the public yesterday.
Similar facilities in Athlone IT and the Midlands Park Hotel remain in operation, while the centre at the Bloomfield House Hotel in Mullingar will open to the public this Thursday.
From today, 59 year olds are invited to register for their vaccine through the HSE's online portal or helpline.