The incident took place in Longford yesterday evening.
Gardai are appealing for witnesses to a serious crash in the Midlands to come forward.
Two men were airlifted to hospital following the incident in Derrylough, Longford.
Gardai and emergency services attended the single vehicle collision on the R392 at around 6:45pm yesterday evening.
One man in his 30s was airlifted to the Mater Hospital in Dublin for treatment of serious injuries.
The second man, also in his 30s, was airlifted to the Midlands Hospital Tullamore, also with serious injuries.
The road was closed for a technical exam last night and diversions were put in place.
Gardai are appealing to anyone who was travelling in the area and has dash cam footage to come forward.
Anyone with any information is asked to contact Longford Garda Station, the Garda Confidential line or any Garda station.
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