Adrian Carberry and Tommy Hewitt's side are looking for first league wins.
Athlone Town will look to back up their win in the FAI Cup when they play Galway United tonight.
The midlanders welcome John Caulfield's new side to Lissywoolen for a 7.45 kick off.
Elsewhere In the First Division, leaders Cabinteely are away to Bray Wanderers,
It's Drogheda United versus Cobh Ramblers, UCD to take on Wexford and Shamrock Rovers Two up against Longford Town.
League Of Ireland 1st division fixtures:
Bray v Cabinteely
Drogheda v Cobh
UCD v Wexford
Longford v Shamrock Rovers II
Premier Division:
St. Patricks Athletic v Waterford
MATCHDAY
— Athlone Town AFC (@AthloneTownAFC) September 4, 2020
We host Galway United tonight at Athlone Town Stadium.
Kick-off is at 7 45pm and we'll have updates on our Twitter page.#CmonTheTown pic.twitter.com/8eaa4poWHW
Meanwhile, Athlone Town ladies also continue their inaugural Women's National League campaign this weekend.
Tommy Hewett's charges take on Treaty United of Limerick at 7 O'Clock tomorrow evening.
They'll be looking for their first win since joining the league.
Women's National League fixtures:
Bohemians v Cork
Galway v Shelbourne
Wexford Youths v Peamount
more photos from peamount v Athlone Town pic.twitter.com/rd0wD3VY0X
— Athlone Town Afc Womens Official (@AfcAthlone) August 31, 2020
Portlaoise Panthers Back In Super League Action This Weekend
Camross Name Tomas Burke As New Hurling Manager
Midlands Stars Set For European Cross Country Championships
Laois U20 Hurler And Footballer Of The Year Revealed
Camross Has Nothing To Lose This Weekend - Arien Delaney
Robbie Henshaw Named To Start For Leinster's Champions Cup Clash
Leinster Glory The Target For Tubberclair This Weekend
Portlaoise Panthers Aiming To End Losing Streak
Camross Getting Set For All Ireland Final
Westmeath Boxers Set To Compete At U17 European Championships
Portlaoise Panthers U20s Seal Semi-Final Place In National Cup
Midlands Beko Club Champions Recognised At Croke Park
CCFL: Four Teams Progress In Combined Counties Shield
Offaly Olympian Reveals Arsenal Dream
Buccaneers Claim First Home Win In Over Two Years
Pat Roe Steps Down As Portarlington Manager
St Michael's And Wheery To Meet In Offaly U20 Football Final
Athlone Town Confirm Two New Signings Ahead Of 2026 Season
Kelly Brady Named Personality of the Year
Former Irish Soccer Legend Backs Offaly Community After Arson Attack