The game takes place in South Africa.
Head coach Scott Beamand has made two changes to his team for Ireland's first WXV Global Series Test.
Neve Jones will win her 50th cap on Saturday against South Africa at the Athlone Stadium in Cape Town.
Jones, Linda Djougang and Eilís Cahill pack down in the front row.
Dorothy Wall replaces Jemima Adams Verling to partner Jane Clohessy in the engine room.
Fiona Tuite-O’Sullivan, captain Erin King and Brittany Hogan make up the back row.
Stacey Flood comes in at fullback to replace Niamh Gallager who doesn't make the squad.
Ballinasloe's Béibhinn Parsons and Robyn O’Connor also start in the back three.
Offaly's Aoife Dalton and Athlone's Anna McGann selected as the midfield partnership, while Emily Lane and Dannah O’Brien are named as the half-backs.
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