Niall Berry's side earned their first win of the season last time out against DCU Mercy.
After a two week break, the Portlaoise Panthers return to action in the MissQuote.ie Super League this weekend.
Niall Berry's side travel to University of Galway Mystics off the back of securing their first win of the season at home to DCU Mercy in their last outing.
Victory here will be the team's first away from home and will be the first time they record back-to-back wins this season.
Their game against University of Galway Mystics gets underway at 4:00pm on Saturday from Kingfisher Sports Arena.
Colaiste Mhuire Mullingar: All Ireland Champions
Dublin Sink Offaly In Camogie
Lowry Looks On Shaky Ground Since Cognizant Collapse
"Unhappy" Laois Leave Fermanagh With Some Regret
Laois Ladies Football Legend Honoured By County Council
Westmeath School Primed For All Ireland Final Shot
Offaly Relegated After Cavan Defeat
Offaly And Longford Chase Semi-Final Spot In Division Four
NFL: Laois Travel To Fermanagh For Crucial Division Three Encounter
Gold Cup Takes Centre Stage On Final Day Of Cheltenham
Offaly TD Demands Stronger Ticket Touting Laws As Six Nations Prices Hit €3k
Offaly Travel To Dublin For Fourth Round Of National Camogie League
Athlone Town Get Title Defence Underway Tomorrow
NFL: Must Win Game For Westmeath In Division Three
Westmeath County Council To Host Civic Reception For Athlone Town
Midlands Players Named In Ireland Squad For Showdown With Scotland
Irish Athletics Legend Ronnie Delany Dies Aged 91
Shane Lowry And Rory McIlroy In Action At Players Championship
NFL: Potential Make Or Break Weekend For Midlands Sides