Luke Ming Flanagan has topped the poll while two Fine Gael candidates will take two seats.
Laois Offaly TD Barry Cowen is set to win a seat in the Midlands Northwest European constituency.
The Fianna Fail TD sits second in the poll, behind Luke Ming Flanagan, while former RTE correspondent Ciarán Mullooly is in poll position to take the fifth and final seat.
Fine Gael are set to take two seats, Nina Carberry and Maria Walsh got over 145,000 first preference votes between them, while Sinn Fein is facing the prospect of having no sitting MEP in the constituency.
Maria Walsh, who is set to be returned to Brussels, says Fine Gael have done better than they could have ever expected:
The fourth count will get underway at the TF Royal in Castlebar at 10am this morning.
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