Luke Ming Flanagan has topped the poll while two Fine Gael candidates will take two seats.
Laois Offaly TD Barry Cowen is set to win a seat in the Midlands Northwest European constituency.
The Fianna Fail TD sits second in the poll, behind Luke Ming Flanagan, while former RTE correspondent Ciarán Mullooly is in poll position to take the fifth and final seat.
Fine Gael are set to take two seats, Nina Carberry and Maria Walsh got over 145,000 first preference votes between them, while Sinn Fein is facing the prospect of having no sitting MEP in the constituency.
Maria Walsh, who is set to be returned to Brussels, says Fine Gael have done better than they could have ever expected:
The fourth count will get underway at the TF Royal in Castlebar at 10am this morning.
IDA Improve Number Of Investments In 2025
Housing Commencements Rise In Midlands
Portiuncula Maternity Alliance Push HSE For Set Timeline On Reinstating Services
Emergency Services Attending Scene Of Westmeath Crash
Taoiseach Under Pressure As Fianna Fáil Discontent Grows
Thousands Of Farmers Descend On Brussels To Oppose Mercosur Trade Deal
Calls Made For Greater Police Presence In Offaly Town
Quarter Of Residents In Laois IPAS Centre Granted Permission To Stay In Ireland
Man Arrested After Attack On Offaly Garda Station
Gardaí Investigating Criminal Damage At Midlands Pharmacy
Midlands County Hosts Water Safety Awards Ceremony
Surge In Respiratory Illness Cases Forces Visiting Restrictions For Midlands Hospital
Midlands MEP Warns Of EU Meat Price Collapse Ahead Of Mercosur Protest
Offaly TDs Raise Community Policing Concerns Following Arson Attack
Fianna Fáil Warns Ireland Must Stay Competitive Amid Minimum Wage Increase
Uisce Eireann Confirms Completion Of Offaly Works
Man Hospitalised With Serious Injuries Following Offaly Crash
Biodiversity Children's Book Launches In Midlands
Over €3.8m In IT And Minor Works Grants Going To Midlands Schools
Midlands Property Prices Continuing To Rise