Luke Ming Flanagan has topped the poll while two Fine Gael candidates will take two seats.
Laois Offaly TD Barry Cowen is set to win a seat in the Midlands Northwest European constituency.
The Fianna Fail TD sits second in the poll, behind Luke Ming Flanagan, while former RTE correspondent Ciarán Mullooly is in poll position to take the fifth and final seat.
Fine Gael are set to take two seats, Nina Carberry and Maria Walsh got over 145,000 first preference votes between them, while Sinn Fein is facing the prospect of having no sitting MEP in the constituency.
Maria Walsh, who is set to be returned to Brussels, says Fine Gael have done better than they could have ever expected:
The fourth count will get underway at the TF Royal in Castlebar at 10am this morning.
Fast Track Citizenship Proposed For Immigrants Serving In Defence Forces
Gardaí Investigating Spate Of Laois Thefts
Westmeath Councillor Wants Short Term Let Planning Exemptions For Self Caterers
Plans For 27-Acre Midlands Soccer Facility Rejected
Laois Senator Rails Against Rent Pressure Zone Legislation
Managers Should Consider Remote Work Where Possible - FRS
Tourism Minister Welcomes Government Short-Term Let Restrictions
Former Portlaoise Prison Assistant Governor Criticises Psychiatric Prisoner Numbers
Midlands Local Authority Submits Plans To Extend Living City Initiative
Laois Commuters Spend Up To Two Hours A Day Travelling To Work
"Clarity, Honesty And Fairness Must Come Before Profits" - Midlands MEP
Rent Increases Hit Westmeath Council Tenants
NUJ Warn Oireachtas AI Threatening Journalism
Midlands Tourism Businesses Awarded For Excellence
Man Accused Of Murder In 5 Star Laois Hotel Pleads Not Guilty
Time To Move On From Bord Bia Bickering - Midlands MEP
Three Midlands Schools In Line For New Special Classes
Two Men Hospitalised Following Midlands Assault
Midlands Wind Farm Opponents Face ‘Uphill Battle’
Laois Councillor Wants Clarity On NDP