At least one other person has been taken to hospital.
Four people have been killed in a multi-vehicle crash on the M6.
It's the second serious collision on roads in the midlands in the last 24 hours.
The fatal crash occurred on the M6 motorway at Poolboy, Ballinasloe at about 7.40 yesterday evening.
Four people were pronounced dead at the scene and their bodies removed to Portiuncula Hospital, Ballinasloe for post mortem examinations at a later date.
At least one other person has been hospitalised with minor injuries.
It's believed a car had been travelling the wrong way down the motorway and hit two other vehicles.
The road is closed both directions between Junctions 14 and 15 this morning to allow for forensic examinations to take place.
Meanwhile,
Two women were seriously injured when three cars collided in Co. Longford yesterday afternoon.
It occurred on the R198 at Cahanagh, Drumlish Road at 2.50.
One driver, woman in her late 50s, is in a serious condition in Tullamore Regional Hospital.
Another woman in her early 50s, driving the second car, was airlifted to Tallaght Hospital in Dublin.
A woman in her 30s who was driving the third car, along with her passengers, a 14 year old girl and 40 year old woman received medical attention at the scene.
Gardaí are appealing to anyone who may have witnessed this collision to come forward.
Any road users who were travelling on the R198 in the townland of Cahanagh, Drumlish Road, Longford yesterday afternoon between 2.30p.m. and 3p.m. and who may have camera footage (including dash cam) is asked to make it available to gardaí.
Anyone with any information is asked to contact Longford Garda Station on 043 3350570, the Garda Confidential Line on 1800 666 111, or any garda station.
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