Elsewhere there were wins for Ballinamere and Coolderry, while Shinrone could only draw.
St Ryanagh's title ambitions took a significant blow over the weekend.
The 20 times champions met last year's winners Kilcormac-Killoughey on Friday with KK running out impressive 4-26 to 0-15 winners in Rath on Friday.
Adam Screeney tops scored for the county champions with 1-6, while Luke O'Connor hit five points for Ryangh's.
The pick of the goals came from Cillian Kiely after a marauding run in the first half.
Elsewhere in Group Two Coolderry bounced back from an opening day defeat to Rynagh's with a good win over Seir Kieran, 1-27 to 2-13.
In the championship's other group, Shinrone were held to a 1-15 to 1-15 draw against Kinnitty, while Ballinamere were five point winners over Belmont in Banagher - 1-22 to 0-19.
Our coverage of the Offaly Senior Hurling Championship is with thanks to Leahy Midland Auctioneers.
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