Johnny Sexton will also miss the game.
Ireland have a number of injuries to contend with ahead of this Saturday's Autumn Nations Cup test against England at Twickenham.
Johnny Sexton and Robbie Henshaw have both been ruled out of the game after picking up injuries in Friday's win versus Wales.
Sexton has a hamstring issue, while Henshaw has a groin strain.
Jacob Stockdale is also a doubt, having missed the Wales match with a calf injury, but Iain Henderson and Shane Daly have returned to training.
Sexton's replacement Billy Burns is currently following the return to play protocols after a head injury, leading to doubts over who will play at outhalf this weekend.
Head coach Andy Farrell has suggested that Conor Murray could be an option in that position, but former Irish international Alan Quinlan thinks it would be a risky move.
Third Time The Charm As Laois Claim Joe McDonagh Cup
Offaly Pupils Become Local Stars After Publishing Bestselling Book
Katie Taylor To Fight At Croke Park In September
Laois And Westmeath Set For Big Tests In Intermediate Camogie Championship
I Knew I Had To Play A Good Round To Win - Ella Cantwell
Mullingar Athletic And Clonaslee United To Clash In Combined Counties Cup Final
Shane Lowry And Rory McIlroy In Contention At Memorial Tournament
There's Serious Competition In The Laois Panel - Mark Dowling
Westmeath Ladies Look To Book All-Ireland Quarter-Final Spot
Alex Dunne Aiming For Big Weekend In Monaco
Offaly Camogie Captain Looking Forward To Kilkenny Clash
Shane Lowry In Action At Memorial Tournament
Laois Aiming To Make It Third Time Lucky In Joe McDonagh Cup Decider
Galway To Host Westmeath On Sunday June 14th
Second Round Draw Made For FAI Cup
Cian Reddy Keeps Up Unbeaten Professional Record
Westmeath Ladies Get Opening Win In All-Ireland Intermediate Championship
Athlone Town Knocked Out Of All-Island Cup
Limerick See Off Offaly In Senior Camogie Championship
Athlone Town Suffer Defeat Away To UCD In First Division