Johnny Sexton will also miss the game.
Ireland have a number of injuries to contend with ahead of this Saturday's Autumn Nations Cup test against England at Twickenham.
Johnny Sexton and Robbie Henshaw have both been ruled out of the game after picking up injuries in Friday's win versus Wales.
Sexton has a hamstring issue, while Henshaw has a groin strain.
Jacob Stockdale is also a doubt, having missed the Wales match with a calf injury, but Iain Henderson and Shane Daly have returned to training.
Sexton's replacement Billy Burns is currently following the return to play protocols after a head injury, leading to doubts over who will play at outhalf this weekend.
Head coach Andy Farrell has suggested that Conor Murray could be an option in that position, but former Irish international Alan Quinlan thinks it would be a risky move.