The Women's Premier Division side had too much firepower for Glentoran in Blanchflower Stadium.
Athlone Town came from behind away from home to win a seven goal contest in the opening game of their Women's All Island Cup campaign.
The midlanders found themselves 2-1 down before going on to beat Glentoran 5-2.
Casey Howe opened the scoring for Ciaran Kilduff's side before goals by Kerry Beattie and Nadene Caldwell meant the hosts were ahead at the break.
Kerryanne Browne levelled before Howe's second put Athlone back in front.
Ciara O'Neill extended their lead before Jesi Rossman put the seal on their victory.
A number of Town's finishes were out of the top drawer:
Athlone return to action this weekend when they face Shelbourne in the Women's Premier Division.
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