Nine people lost their lives in Laois, Offaly and Westmeath.
More than 5% of deaths on Irish roads in 2019 occurred in the Midlands.
Offaly had the most fatal collisions with five people losing their lives.
Three people died in Westmeath while one person lost their life on the roads in Laois.
In total 148 people died over the course of the year.
Sunday was the most dangerous day to be on the road with over one in five deaths occuring on that day.
Thursday and Friday were the next dangerous.
Deaths of drivers increased by 31 from 2018 to 2019 - with one in ten of people who died in cars found to be not wearing a seat-belt at the time of the accident.
Overall the data released by the Road Safety Authority shows a 4% increase in collisions and deaths in the last 12 months.