The incident took place in Longford yesterday evening.
Gardai are appealing for witnesses to a serious crash in the Midlands to come forward.
Two men were airlifted to hospital following the incident in Derrylough, Longford.
Gardai and emergency services attended the single vehicle collision on the R392 at around 6:45pm yesterday evening.
One man in his 30s was airlifted to the Mater Hospital in Dublin for treatment of serious injuries.
The second man, also in his 30s, was airlifted to the Midlands Hospital Tullamore, also with serious injuries.
The road was closed for a technical exam last night and diversions were put in place.
Gardai are appealing to anyone who was travelling in the area and has dash cam footage to come forward.
Anyone with any information is asked to contact Longford Garda Station, the Garda Confidential line or any Garda station.
Uisce Eireann Working To Repair Burst Watermains in Westmeath
Laois Councillor Outlines 'Life Changing Experience' On Humanitarian Trip
Volunteers Encourage People Across Westmeath To Hang Up County Flags
Lough Ree RNLI Issue Bank Holiday Water Safety Appeal
Laois Village Raises €170k For New Sports Amenity
Midlands Records Over 100 Homeless Children In April
Gardai Bank Holiday Operation Clocks Speeding Midlands Drivers
Irish Online Shoppers Facing Higher Customs Charges From July
Offaly Bond Holder Wins €500k
Muintir na Tíre Host Property Marking In Offaly
Gardaí Pick Up Early Midlands Speeders On June Bank Holiday Weekend
Plans In Place For Laois Housing Development
Water Network Upgrades In Laois
Ministers Burke And Dillon Announce New Employment Permits
Carlow County Council Encourages Creatives To Apply To CUBE Craft Academy In Greece
Midlands Gears Up For Vibrant June Bank Holiday Weekend
HSE Midlands Points To Care Options Ahead Of Bank Holiday
Laois TD Criticising An Coimisiún Pleanála Planning Delays
Offaly Brothers Found Not Guilty Of Attempted Murder
Midlands MEP Wants CAP Funding Boost For Young Farmers