Gardaí are asking motorists to avoid the area.
Emergency services are at the scene of crash in Offaly.
The two-vehicle collision occurred on the N52 road from Tullamore to Kilbeggan at 1.25 this afternoon.
One of the drivers, a man in his 80s, was taken by ambulance to Midlands Regional Hospital Tullamore.
His condition is understood to be serious.
The driver of the second vehicle was treated at the scene for minor injuries.
Gardaí are asking motorists to avoid the area.
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