Its incidence of the virus was more than double the national average.
Westmeath has the highest incidence rate of covid-19 in Ireland over Christmas - more than double the national average.
The latest figures from the Health Protection Surveillance Centre show the Lake County had a rate of 3,056 cases per 100,000 people.
Clare and Kilkenny make up the top three.
Laois has the fifth highest rate in the country, at 1,799, followed by Offaly at 1,729.
The median aged of those who contracted the virus in the midlands is 29.
5,494 cases of covid-19 were confirmed in the midlands over Christmas.
Westmeath was worst affected, with 2,713 infections recorded, followed by 1,464 in Laois, and 1,317 in Offaly.
That accounts for 8.5 per cent of the 65,044 cases reported in Ireland in the last week of 2021.
However, the true number of cases is expected to be higher.
The HSE estimates up to 150,000 infections may have escaped official confirmation, due to the high demand for PCR tests.
Westmeath Waste Facility Remains Temporarily Closed
Laois Man To Be Laid To Rest Friday
Laois Community Safety Partnership To Start January
Midlands Community Groups To Get Communication Grants
Offaly Community Shop Highlights Services
Offaly TD Urges Action On Student Accomodation
Laois County Council Urge Continued STEM EU Just Transition Funding
EU Set To Unveil Housing Package As Fiscal Rules Face Relaxation
Midlands Driving Instructor Calls For Mandatory Alcolock System
Westmeath Family Into Final Of Ireland's Fittest Family
Motion Calls For HSE Investigation Into Wind Turbine Noise Passed In Offaly
Irish Farmers Head To Brussels On Tractors To Protest EU Policies
Man Arrested Over Alleged Assault At Midlands Prison
Emergency Services Attend Westmeath Car Fire
Unanimous Vote Supports €20m Midlands Hospice Project
Drink Driving Rider Arrested After Illegal E-Scooter Seized In Offaly
Drug-Driving Surge Sparks Calls For Christmas Crackdown
Revenue Seize Over €243k In Contraband In The Midlands
Midlands Hospice Planning Application Passed By Offaly County Council