The Irish Penal Reform Trust is urging immediate intervention.
A third of all deaths in prisons last year took place in the Midlands.
Of the 31 inmates who died while in custody, 9 occurred in Midlands Prison, with one in Portlaoise Prison.
The Office of the Inspector of Prisons' annual report for 2024 states conditions for some inmates are "inhumane" and "degrading".
The Irish Penal Reform Trust is calling for urgent action.
Its Executive Director, Saoirse Brady says the report paints a very bleak picture:
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