They will be on the lookout for drink-driving and speeding offences.
Gardaí will be out in force in the midlands over the bank holiday weekend, monitoring road usage.
There will be a particular emphasis on intoxicated driving, speeding, seatbelt offences, and using a mobile phone while driving.
There have been 101 deaths on Irish roads so far this year, 10 of those were in the midlands.
An Garda Síochana's Road Safety Campaign will be in place until Wednesday.
Superintendent at Portlaoise Garda Station, Eamon Curley, is encouraging everyone to behave responsibly on the road this weekend:
Gardaí arrested 25 people last night for driving under the influence of alcohol or drugs.
It comes as a nationwide road safety operation will run across the August Bank Holiday weekend.
Assistant Commissioner for Roads Policing, Paula Hilman, is urging people never to drive under the influence:
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