A woman was also seriously injured in the incident.
Two children have died in a car fire in Westmeath.
A woman was also seriously injured in the incident, which occurred around 4 o'clock today.
She was taken by air ambulance from the scene in Multyfarnham to a Dublin hospital for treatment.
An infant boy was removed from the scene by ambulance to Midland Regional Hospital, Mullingar. He has since been pronounced dead.
The remains of a young girl were also discovered at the scene.
Gardaí are investigating the incident and say enquiries are on going.